副猪嗜血杆菌感染:宿主免疫应答模型与巨噬细胞活化

doi:10.11843/j.issn.0366-6964.2015.01.001

Abstract

Abstract:

Haemophilus parasuis(HPS) is one of the main virulent bacteria that threating the pig industry worldwide.HPS infection typically causes serious inflammations，namely Glässer’s disease.But there are still many troubles in disease prevention and control.Though much progress has been made in the basic research fields of bacterial virulent factors and host immune responses(IR) recently，the mechanisms of host-bacillus interaction are largely unknown.As the different susceptibilities in pigs exist，genomic selection based on molecular breeding strategy will receiving increasing attention from scientists and commercial breeders.Here，some high through-out data from our and other labs are reviewed in brief and the model for the host IR is proposed.We hypothesize that the activation of macrophage during the early stage of IR may play pivotal roles in determining bacillus escape and/or host protective IRs.In addition，key molecules and pathways involved in the IR of macrophage are discussed，which we hope will be helpful for the marker identifications in objectives of molecular breeding.Still，there is much work to be done and some suggestions are proposed in the article.

CLC Number:

S852.61

CHEN Hong-bo. Haemophilus parasuis Infection：Model for the Host Immune Response and the Macrophage Activation[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(1): 1-11.

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Haemophilus parasuis Infection：Model for the Host Immune Response and the Macrophage Activation

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